Synthesis of Ultra-Large Fibrous Proteins from Bacteria via a Looped-Translation System
Qi Xie, Louis J. Papa, Anton M. Barybin, Michael Xiong, Matthew D. Shoulders, Stephen D. Fried
This paper develops a looped-translation system in bacteria to synthesize ultra-large fibrous proteins, achieving molecular weights exceeding titin and enabling secretion.
bioRxiv · Jul 17, 2026 · PreprintSynthetic Biology