Author

Kathryn M. Yammine

Massachusetts Institute of TechnologyORCID 0000-0003-4875-4103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:ecology & biodiversity· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Agata A. BikovtsevaiD· 2 shared John F. BatemaniD· 2 shared Matthew D. ShouldersiD· 2 shared Richard P. SchiavoniiD· 2 shared Seo-yeon KimiD· 2 shared Shireen R. LamandéiD· 2 shared Sophia Mirda AbularachiD· 2 shared Vincent L. ButtyiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersCell Biology

Agata A. BikovtsevaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rapid adaptive evolution of microbial thermal performance curves

Megan H. Liu, Ze‐Yi Han, Yaning Yuan, Katrina DeWitt, Daniel J. Wieczynski, Kathryn M. Yammine, Andrea Yammine, Rebecca A. Zufall, Adam M. Siepielski, Douglas L. Chalker, Masayuki Onishi, Fabio A. Machado, Jean P. Gibert

This study shows how genetic and environmental factors shape microbial thermal performance curves and their evolution under temperature changes.

Communications Biology · Apr 15, 2026Peer-reviewedEcology

Loss of adenylosuccinate synthetase 1 in mice recapitulates features of ADSS1 myopathy

M. Kim, Kathryn M. Yammine, Emily T Hickey, Catalina Matias, Lou C Dubosclard, Jeffrey J. Widrick, Jeffrey J. Brault, Behzad Moghadaszadeh, Alan H. Beggs

This paper presents a mouse model of ADSS1 myopathy by knocking out Adss1 and characterizes its motor deficits and histopathological features.

Human Molecular Genetics · Nov 20, 2025Peer-reviewedGenetics

Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a COL2A1-Related Osteoarthritis

Kathryn M. Yammine, Sophia Mirda Abularach, Michael Xiong, Seo-yeon Kim, Agata A. Bikovtseva, Vincent L. Butty, Richard P. Schiavoni, John F. Bateman, Shireen R. Lamandé, Matthew D. Shoulders

This study uses iPSC-derived cartilage to show that the Arg719Cys COL2A1 mutation causes defective proteostasis, leading to abnormal matrix deposition and disease.

Journal of Biological Chemistry · Jul 1, 2025Peer-reviewedCell Biology

Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a COL2A1-Related Osteoarthritis

Kathryn M. Yammine, Sophia Mirda Abularach, Michael Xiong, Seo-yeon Kim, Agata A. Bikovtseva, Vincent L. Butty, Richard P. Schiavoni, John F. Bateman, Shireen R. Lamandé, Matthew D. Shoulders

The paper develops an iPSC-derived cartilage model to study COL2A1 mutations, revealing that Arg719Cys substitution causes defective collagen-II folding and secretion, leading to matrix dysfunction and osteoarthritis.

Life Science Alliance · Jul 9, 2024Peer-reviewedGenetics