A dNmnat-sensitized in vivo platform for unbiased discovery of regulators of neurodegeneration
A. A. Avetisyan, Ernesto Manzo, Romina Barria, Magdalena Kocia, Jiun-Min Hsu, Alexandra Larson, Rachel Weirnick, Kavya Balasubramanian, Nathan Blackwell, Micheal Freeman, Dana M. Bis‐Brewer, Sarah Fazal, Stefan Schüchner, Lukas Jakob Neukomm, Marc Freeman
This paper develops a genetic screening platform in Drosophila to identify regulators of axon degeneration by depleting dNmnat, revealing new factors that influence neuronal survival and NAD+ homeostasis.
bioRxiv · Sep 25, 2025 · PreprintNeuroscience