Lukas Jakob Neukomm

This paper develops a genetic screening platform in Drosophila to identify regulators of axon degeneration by depleting dNmnat, revealing new factors that influence neuronal survival and NAD+ homeostasis.

The paper shows that local translation sustains synaptic function in impaired Wallerian degeneration by identifying mTOR and related pathways involved in protein synthesis and calcium homeostasis.

This study identifies Orion, a chemokine-like ligand, as essential for glial cell transformation into phagocytes during neuronal remodeling and debris clearance.

This study shows that reducing NMN levels in Drosophila prevents axon degeneration and neurodegeneration, revealing NMN's role in axon injury and disease.