Marc R. Freeman

This study identifies glial Croquemort as a key regulator of synapse elimination during development and aging in Drosophila.

This study identifies ANIDRA as a Drosophila amino acid transporter that regulates sleep by modulating mTOR activity in glia and affecting arousal-promoting neurons.

The paper introduces a CRISPR-Cas13d-based system for cell-specific mRNA knockdown in zebrafish, validated across CNS glia types, showing efficient target mRNA depletion and reproducible phenotypes.

The paper identifies HIF-1 as a regulator of Sarm1-mediated neurodegeneration, showing that stabilized HIF-1 prevents NAD+ loss and protects neurons.

This paper develops a genetic screening platform in Drosophila to identify regulators of axon degeneration by depleting dNmnat, revealing new factors that influence neuronal survival and NAD+ homeostasis.

This study determines the structure of the LPD-3 BLTP complex and reveals its mechanism for bulk lipid transfer through interactions with Intake and Spigot proteins.

The paper identifies dWnk as an ionic/osmotic sensor that promotes neurodegeneration alongside dSarm in Drosophila, converging on Axundead for axon death.

This study identifies adrenergic signaling as a gatekeeper for astrocyte responses to neurotransmitters, showing its role in regulating neuronal activity and behavior in both Drosophila and mammals.

The paper identifies Tre1 and S1pr1 as evolutionarily conserved regulators of astrocyte morphology through lipid signaling and competition for growth-promoting phospholipids.

The paper identifies two neuronal subtypes in Drosophila that undergo distinct remodeling processes during metamorphosis, highlighting astrocyte-dependent pruning and Hox gene-mediated cell death.

This study shows Tweek is essential for astrocyte phagocytosis and ER-PM contact formation during neuronal remodeling in Drosophila.

This study identifies Ddr as a key regulator of non-myelinating glial ensheathment and its role in axon survival and caliber in Drosophila.

The paper identifies glial TGFβ signaling as essential for axon survival and shows its loss leads to age-dependent neurodegeneration.

This study shows that the astrocytic GABA transporter GAT modulates sleep in Drosophila by affecting GABAergic signaling in circadian neurons.

The paper develops a GFP-based ELISA assay for rapid, quantitative genetic screens in Drosophila, identifying Syntaxins as novel regulators of astrocyte-mediated synapse elimination.

The paper identifies astrocytes as essential for closing the critical period of motor circuit plasticity in Drosophila by regulating dendrite morphology and locomotor behavior through Neuroligin-Neurexin signaling.

The paper shows that TrpML-mediated astrocyte microdomain Ca2+ transients regulate tracheal filopodial retraction and CNS gas exchange in Drosophila.