Ernesto Manzo

This paper develops a genetic screening platform in Drosophila to identify regulators of axon degeneration by depleting dNmnat, revealing new factors that influence neuronal survival and NAD+ homeostasis.

This study identifies adrenergic signaling as a gatekeeper for astrocyte responses to neurotransmitters, showing its role in regulating neuronal activity and behavior in both Drosophila and mammals.

The paper shows that increased glycolysis is neuroprotective in ALS by improving locomotion and lifespan in Drosophila models through glucose transporter and PFK overexpression.