The Tryptophan Metabolizing Enzyme Indoleamine 2,3-Dioxygenase 1 Regulates Polycystic Kidney Disease Progression
Dustin T. Nguyen, Emily K. Kleczko, Nidhi Dwivedi, Marie‐Louise T. Monaghan, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Raphael A. Nemenoff, Jost Klawitter, Katharina Hopp
This study shows that IDO1 inhibition reduces ADPKD severity by altering the cystic immune microenvironment.
JCI Insight · Nov 24, 2022Peer-reviewedMolecular Biology