Cancer BiologybioRxiv
Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia
Sunniyat Rahman, Gianna Bloye, Nadine Farah…·Marc R. Mansour
The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.
DOI 10.1182/blood.2024024300