Author

Alejandro Gutierrez

Boston Children's HospitalORCID 0000-0002-0249-9007Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Alejandro Gutierrez1 paper · The University of Texas at Austin

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Raja Hussain AliiD· 2 shared Richard I. GregoryiD· 2 shared Abigail Fish· 1 shared Adrianne D. GladdeniD· 1 shared Anais Barthe· 1 shared Anais Torres· 1 shared Angelo D'AlessandroiD· 1 shared Chi-Lun ChangiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

Raja Hussain AliORCID

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Author profile →

4 papers

Recent·Most cited

Choline kinase A is required for alkylating agent resistance via lipid droplet formation

Abigail Fish, Kimberly Bodaar, Anais Barthe, Haven Griffin, Hasan Al Reza, Wojciech Rosikiewicz, Eric Aboagye, Julie R Reisz, Angelo D'Alessandro, Chi-Lun Chang, Alejandro Gutierrez

This study identifies CHKA's role in alkylating agent resistance through lipid droplet-mediated regulation of RAD51 transcription in T-ALL.

bioRxiv · Nov 9, 2026 · PreprintCell Biology

Targeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesis

Esteban A. Orellana, Isobel E. Bowles, Xin Yang, Anais Torres, Sally Jamieson, Raja Hussain Ali, Alejandro Gutierrez, Richard I. Gregory

This study identifies tRNA-Arg-TCT-4-1 as a new anti-cancer therapeutic target and shows that targeting it with an ASO suppresses tumorigenesis and extends survival in mouse models.

bioRxiv · Feb 20, 2026 · PreprintCancer Biology

ADAT2/3-mediated tRNA editing promotes cancer cell growth and tumorigenicity

Julia Ramírez-Moya, Titi Rindi Antika, Qi Liu, Xushen Xiong, Raja Hussain Ali, Alejandro Gutiérrez, Richard I. Gregory

This study shows that ADAT2/3-mediated tRNA editing supports cancer cell growth and tumorigenicity by enhancing translation of growth-promoting mRNAs.

Journal of Molecular Biology · Sep 2, 2025Peer-reviewedCancer Biology

HCR-FlowFISH: A flexible CRISPR screening method to identify cis-regulatory elements and their target genes

Steven K. Reilly, Sager J. Gosai, Alejandro Gutiérrez, Jacob C. Ulirsch, Masahiro Kanai, Daniel Berenzy, Susan Kales, G E Butler, Adrianne D. Gladden, Hilary K. Finucane, Pardis Christine Sabeti, Ryan Tewhey

HCR-FlowFISH identifies cis-regulatory elements and their target genes by quantifying gene expression changes after CRISPR perturbations, using >270,000 perturbations to detect CREs for multiple genes.

bioRxiv · May 11, 2020 · PreprintGenomics