Engineering Antibody-Drug Conjugates targeting an Adhesion GPCR, CD97
Takamitsu Hattori, Michelle Y. Wang, Alexis D. Corrado, Suzanne Gross, Michelle Fang, Injin Bang, Nainita Roy, Iryna Berezniuk, Hayley Donaldson, Karenna J. Groff, Niklas Ravn-Boess, Akiko Koide, Dimitris G. Placantonakis, Christopher Y. Park, Shohei Koide
This study develops antibody-drug conjugates targeting CD97, an aGPCR overexpressed in cancer, showing efficacy against AML and GBM cells with minimal off-target toxicity.
Proceedings of the National Academy of Sciences · Sep 30, 2025Peer-reviewedBiochemistry