Christopher Y. Park

Volaria integrates coding and regulatory variation into gene-centered representations for disease outcome prediction using whole-genome sequencing data.

This study develops antibody-drug conjugates targeting CD97, an aGPCR overexpressed in cancer, showing efficacy against AML and GBM cells with minimal off-target toxicity.

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

This study maps the spatial and single-cell landscape of Castleman Disease, identifying key stromal cell types and cytokine pathways involved in disease pathology.

This study shows that acute inhibition of iron-sulfur cluster biosynthesis in mice leads to metabolic inflexibility, reduced adiposity, and glucose dyshomeostasis, with effects mitigated in aged mice.