Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome
Federica Riccio, Guilherme Neves, Michelle Gottlieb-Marra, Ariana P. Gatt, Christina E. Toomey, Jernej Ule, Ivo Lieberam, Juan Burrone
The paper shows that increased HCN1 activity in excitatory neurons causes excessive network bursting in Dravet syndrome, suggesting HCN1 as a therapeutic target.
bioRxiv · Oct 3, 2025 · PreprintNeuroscience