Synthetic BiologyFrontiers in Synthetic BiologyPeer-reviewed
Evolving a mitigation of the stress response pathway to change the basic chemistry of life
Isabella Tolle, Stefan Oehm, Michael Georg Hoesl…·Nediljko Budiša
This paper uses adaptive laboratory evolution to replace tryptophan in E. coli with a synthetic analog, revealing that stress response inhibition, not translation rigidity, limits genetic code expansion.
17 citations