Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome.
Gareth Chapman, Mouhamed Alsaqati, Sharna Lunn, Tanya Singh, Stefanie Caroline Linden, David E.J. Linden, Marianne B. M. van den Bree, Mike Ziller, Michael John Owen, Jérémy Hall, Adrian J. Harwood, Yasir Ahmed Syed
This study investigates the effects of 1q21.1 deletion and duplication on neuronal development using induced pluripotent stem cells and shows reciprocal phenotypes and potential therapeutic targets.
Molecular Psychiatry · Jun 10, 2021Peer-reviewedNeuroscience