Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 mutations
Zhihui Zhang, Matthew A. Simon, Yuan Liang, Alexander Tyshkovskiy, Mila Kaplan, Victoria Paige, Seyed Ali Biashad, Vadim N. Gladyshev, Andrei Seluanov, Vera A. Gorbunova
This study shows that SIRT6 Serine 10 mutations in mice affect DNA repair, LINE1 expression, and lifespan, with reduced LINE1 control having a stronger impact on lifespan than enhanced DNA repair.
bioRxiv · Feb 6, 2026 · PreprintMolecular Biology