Matthew A. Simon

This paper develops an automated machine vision-based index for Rett Syndrome that improves preclinical phenotyping by detecting disease-relevant behaviors and reducing animal use.

This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.

This study shows that SIRT6 Serine 10 mutations in mice affect DNA repair, LINE1 expression, and lifespan, with reduced LINE1 control having a stronger impact on lifespan than enhanced DNA repair.

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

The paper shows that prg-1 mutant C. elegans germ cells transmit heritable stress that promotes longevity but reduces fertility, with effects observed in F1 progeny.

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

This paper identifies a meiosis-specific function of the phosphatase GSP-2 in promoting germ cell immortality through small RNA-mediated genome silencing in C. elegans.