Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers
Andreas Stephanou, Madhav Mantri, Divya Shankaranarayanan, Carol Li, Mila Lagman, Jenny Xiang, Chendong Pan, Yanjie Sun, Thangamani Muthukumar, Khaled Machaca, Iwijn De Vlaminck, Manikkam Suthanthiran
This study uses single-cell RNA sequencing to show that SOCE blockers BTP2 and CM4620 reduce cytotoxicity in CD8 T cells and NK cells while preserving anti-inflammatory programs in CD4 Tregs.
Human Immunology · Feb 13, 2026Peer-reviewedImmunology