Manikkam Suthanthiran

The paper quantifies the direct relationship between Banff acute lesion scores and a urinary cell three-gene signature, showing strong associations with acute rejection pathology.

This study uses single-cell RNA sequencing to show that SOCE blockers BTP2 and CM4620 reduce cytotoxicity in CD8 T cells and NK cells while preserving anti-inflammatory programs in CD4 Tregs.

The paper introduces Coffee-seq, a metagenomic DNA sequencing method that reduces environmental contamination, and applies it to detect infections and microbial signatures in clinical samples.

This study uses scRNA-seq to analyze kidney allograft biopsies and identifies recipient-derived fibroblasts and other cell states associated with fibrosis and rejection.

The paper introduces LBBC, a tool to reduce noise in metagenomic cfDNA sequencing, improving detection of urinary tract infection while minimizing false positives.

This paper introduces a cell-free DNA metagenomic sequencing assay that integrates host damage response to infection, showing it can accurately capture microbial composition and tissue damage in urinary tract infections.

This study uses urinary cell-free DNA to monitor host and pathogen dynamics in urinary tract infections, revealing insights into microbiome composition, antimicrobial susceptibility, and kidney injury.

The paper predicts long-term kidney graft function using exome sequencing by analyzing amino acid mismatches between recipients and donors.