Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions
Colin O’Hern, Sammantha Caywood, Shakhlo Aminova, Artem M. Kiselev, Brett D. Volmert, Fei Wang, Merlinda-Loriane Sewavi, Weiheng Cao, Mia Dionise, Priyadharshni Muniyandi, Mirel Adrian Popa, Hussain F. Basrai, Milana Skoric, George Boulos, Amanda Huang, , Aitor Aguirre
This paper introduces hHMA, a human heart-macrophage assembloid model that integrates autologous cardiac macrophages with heart organoids to study immune-cardiac interactions and disease mechanisms.
bioRxiv · Nov 13, 2024 · PreprintBioengineering