Aitor Aguirre

Network-enabled drug repurposing identifies lithium to promote cardiomyocyte proliferation

This paper uses a computational framework to identify FDA-approved drugs that can promote cardiomyocyte proliferation, finding lithium as a potential therapeutic but highlighting congenital risks.

Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

The Tricuspid Valve is Transcriptionally Active During Prolonged Pressure Overload, Right-Sided Heart Failure, and Valve Regurgitation

This paper uses a sheep model of right-sided heart failure to identify transcriptional changes in the tricuspid valve and other cardiac tissues, highlighting sex-specific and disease-related gene expression patterns.

A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment

The paper identifies YAP1 as a non-canonical effector of RA signaling essential for atrial lineage commitment in cardiac progenitor cells.

Self-organizing human heart assembloids with autologous and developmentally relevant cardiac neural crest-derived tissues

This paper develops a human heart assembloid model that recapitulates cardiac neural crest integration and reveals antidepressant effects on cardiac development.

Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions

This paper introduces hHMA, a human heart-macrophage assembloid model that integrates autologous cardiac macrophages with heart organoids to study immune-cardiac interactions and disease mechanisms.

Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury

This study shows that oxytocin promotes epicardial cell activation and heart regeneration in both mammals and zebrafish by inducing proliferation, EMT, and migration through the TGF-β pathway.