Slow diffusion and signal amplification on membranes regulated by phospholipase D
Gen Honda, Chihuku Tanaka, Hidenori Hashimura, Tomoko Adachi, Mina Fujishiro, Nao Shimada, Satoshi Sawai, Miho Yanagisawa
This study shows phospholipase D (PLD) reduces lipid and protein diffusion in membranes by producing phosphatidic acid, which affects phosphoinositide signaling and membrane protrusion.
Proceedings of the National Academy of Sciences · May 13, 2026Peer-reviewedBiophysics