Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity
Rishi V. Puram, Qiangzong Yin, YuhJong Liu, Justine C. Rutter, Daniel P. Bondeson, Maria C. Saberi, Lisa A. Miller, Michael Yifei Du, Khanh Nguyen, Donovan L. Batzli, Hilina B. Woldemichael, Christian Taeger, Anna Goldstein, Ming Y. Chu, Qi Guo, , Todd R. Golub
This study identifies DNA hypomethylation, not DNA damage, as the primary mechanism of azacytidine and decitabine anti-cancer activity, linking it to chromatin regulators like USP48.
bioRxiv · Jul 29, 2025 · PreprintCancer Biology