Author

Justine C. Rutter

Broad InstituteORCID 0000-0002-0851-0887Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mikolaj Michal SlabickiiD· 2 shared Anna Goldstein· 1 shared Blanche C. IpiD· 1 shared Christian Taeger· 1 shared D.R. ManiiD· 1 shared Daniel P. BondesoniD· 1 shared Donovan L. Batzli· 1 shared Gandhar K. DatariD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Mikolaj Michal SlabickiORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity

Rishi V. Puram, Qiangzong Yin, YuhJong Liu, Justine C. Rutter, Daniel P. Bondeson, Maria C. Saberi, Lisa A. Miller, Michael Yifei Du, Khanh Nguyen, Donovan L. Batzli, Hilina B. Woldemichael, Christian Taeger, Anna Goldstein, Ming Y. Chu, Qi Guo, , Todd R. Golub

This study identifies DNA hypomethylation, not DNA damage, as the primary mechanism of azacytidine and decitabine anti-cancer activity, linking it to chromatin regulators like USP48.

bioRxiv · Jul 29, 2025 · PreprintCancer Biology

Stability and DNA Methyltransferase Activity of DNMT3A are Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation

Taishi Yonezawa, Justine C. Rutter, Raghav Ramabadran, Venkatasubramaniam Sundaramurthy, Gandhar K. Datar, Mikolaj Michal Slabicki, Margaret A. Goodell

This study identifies USP11 and SUMOylation as critical for maintaining DNMT3A stability and function, offering potential therapeutic strategies for diseases linked to DNMT3A instability.

bioRxiv · Mar 5, 2025 · PreprintBiochemistry