HIV-1 Vpr causes separate cell cycle arrests in G2 and M that activate alternative DNA damage pathways
Ross Hall, Lucy M. Ahern, Melvyn W. Yap, Ming-Han Tsai, Virginie Boucherit, Tohru Takaki, Simon J. Boulton, Kate N. Bishop
This paper shows HIV-1 Vpr causes separate G2 and M phase cell cycle arrests that activate distinct DNA damage pathways, with implications for early HIV replication.
bioRxiv · Apr 2, 2024 · PreprintMicrobiology