Melvyn W Yap

Human-like APOBEC3 gene expression and anti-viral responses following replacement of mouse Apobec3 with the 7-gene human APOBEC3 locus

This study creates a mouse model with human APOBEC3 genes to study their expression and anti-viral functions, showing human-like regulation and functional responses.

HIV-1 Vpr causes separate cell cycle arrests in G2 and M that activate alternative DNA damage pathways

This paper shows HIV-1 Vpr causes separate G2 and M phase cell cycle arrests that activate distinct DNA damage pathways, with implications for early HIV replication.