K63-linked ubiquitin chains mark inactive Smoothened for packaging into ciliary extracellular vesicles
Mingli Zhu, Yash Raj, Gary Andrew Bradshaw, David U. Mick, Marian Kalocsay, Maxence V. Nachury
The paper identifies K63-linked ubiquitin chains as a sorting signal for ciliary ectocytosis, showing that ubiquitinated inactive Smoothened is packaged into ciliary extracellular vesicles.
bioRxiv · Jul 17, 2026 · PreprintCell Biology