Maxence V. Nachury

The paper identifies K63-linked ubiquitin chains as a sorting signal for ciliary ectocytosis, showing that ubiquitinated inactive Smoothened is packaged into ciliary extracellular vesicles.

The paper uses in situ proteomics to show neuronal cilia have specialized nanodomains for extrasynaptic signaling, enriched in synaptic proteins and neurotransmitter receptors.

This study identifies IMPG2m as a BBSome cargo in photoreceptors, revealing a constitutive ciliary retrieval pathway involving ubiquitinated membrane proteins.

This study shows that MRAP2 is essential for MC4R's localization to primary cilia and its role in regulating energy homeostasis and body weight.

This study uses a CRISPR-based screen to identify genes critical for Hedgehog signaling and ciliary function, revealing novel components of ciliary structures and linking congenital heart defects to ciliopathies.