Membrane contact site resident PTP1B limits superoxide production by suppressing a Syk-Shc1-Phagocyte Oxidase relay.
Minhyoung Lee, Haggag S. Zein, Mahlegha Ghavami, Kuiru Wei, Murtaza Lokhandwala, Kaitlin Chan, Leanne E. Wybenga-Groot, Michael F. Moran, Gregory D. Fairn
This study identifies PTP1B's role in suppressing superoxide production during phagocytosis by inhibiting the SFK-Syk-Shc1-NOX2 signaling pathway at ER-PM membrane contact sites.
bioRxiv · Apr 30, 2026 · PreprintCell Biology