Leanne E. Wybenga-Groot

Membrane contact site resident PTP1B limits superoxide production by suppressing a Syk-Shc1-Phagocyte Oxidase relay.

This study identifies PTP1B's role in suppressing superoxide production during phagocytosis by inhibiting the SFK-Syk-Shc1-NOX2 signaling pathway at ER-PM membrane contact sites.

Targeting CBL ubiquitin ligase activation to downregulate tyrosine kinase signalling

This study demonstrates that activating CBL ubiquitin ligase via engineered mutants or small molecules can downregulate tyrosine kinase signaling by enhancing substrate ubiquitination and reducing downstream signaling.

Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

SLAP2 adaptor binding disrupts c-CBL autoinhibition to activate ubiquitin ligase function.

This study identifies how SLAP2 binding to CBL disrupts its autoinhibition, revealing a mechanism for activating CBL's ubiquitin ligase function.

Evosep One Enables Robust Quantitative Deep Proteome Coverage using Tandem Mass Tags while Significantly Reducing Instrument Time

The paper demonstrates that Evosep One technology enables faster quantitative proteome analysis with comparable coverage to conventional methods.