Cell BiologybioRxivPreprint
Membrane contact site resident PTP1B limits superoxide production by suppressing a Syk-Shc1-Phagocyte Oxidase relay.
Minhyoung Lee, Haggag S. Zein, Mahlegha Ghavami…·Gregory D. Fairn
This study identifies PTP1B's role in suppressing superoxide production during phagocytosis by inhibiting the SFK-Syk-Shc1-NOX2 signaling pathway at ER-PM membrane contact sites.
DOI 10.64898/2026.03.17.711902