Michael F. Moran

This study identifies PTP1B's role in suppressing superoxide production during phagocytosis by inhibiting the SFK-Syk-Shc1-NOX2 signaling pathway at ER-PM membrane contact sites.

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

This study identifies how SLAP2 binding to CBL disrupts its autoinhibition, revealing a mechanism for activating CBL's ubiquitin ligase function.

The paper introduces DDIA, a method combining DDA and DIA in a single LC-MS/MS run, with a complete data processing pipeline and minimal data requirements.

The paper demonstrates that Evosep One technology enables faster quantitative proteome analysis with comparable coverage to conventional methods.

This study shows that high non-driver somatic alteration burden in NSCLC is linked to better prognosis, including improved survival and immune response.