Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity
Xuemeng Sun, Anita Donlic, Jacob A. Boyer, Theodore E. Press, Minjae Kim, Neal K. Reddy, Clifford P. Brangwynne, Joshua D. Rabinowitz, Ralph E. Kleiner
This study investigates the metabolism of epigenetic ribonucleosides in human cells, revealing cytotoxic effects and mechanisms of RNA misincorporation and nucleolar stress.
ACS Chemical Biology · Mar 6, 2026Peer-reviewedBiochemistry