Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.
Jessica T. Root, Anarmaa Mendsaikhan, Srijita Nandy, Georgia Taylor, Minzheng Wang, Ludmilla Troiano Araujo, Paola Merino, Danny Ryu, Christopher J. Holler, Bonne M. Thompson, Giuseppe Astarita, Jean‐François Blain, Thomas L. Kukar
This study shows that individual granulins can rescue disease pathology in PGRN-deficient mice, suggesting they are functional units of PGRN with therapeutic potential.
bioRxiv · Apr 17, 2023 · PreprintNeuroscience