Microglia regulate developmental transitions in synaptic plasticity rules in the medial prefrontal cortex
Mio Tajiri, Hidefumi Omi, Airi Inoue, Hayato Etani, Takeshi Sawada, Yusuke Iino, Sho Yagishita
This study shows microglia regulate the shift from Hebbian to three-factor plasticity rules in the medial prefrontal cortex during development, affecting social learning and pain sensitivity.
bioRxiv · Jun 16, 2025 · PreprintNeuroscience