Author

Tatsushi Yokoyama

Kyoto UniversityORCID 0000-0001-7159-9039Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:fluorescence / live-cell microscopy· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Masayuki SakamotoiD· 4 shared Akihiro KusumiiD· 2 shared Kazuo KitamuraiD· 2 shared Peng ZhouiD· 2 shared Rinshi S. KasaiiD· 2 shared Satoshi ManitaiD· 2 shared Simone Pigolotti AiD· 2 shared Taka Aki TsunoyamaiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Masayuki SakamotoORCID

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4 papers

Recent·Most cited

Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo

Shigenori Inagaki, Nao Nakagawa-Tamagawa, Nathan Huynh, Yuki Kambe, Rei Yagasaki, Satoshi Manita, Satoshi Fujimoto, Takahiro Noda, Misato Mori, Aki Teranishi, Hikari Takeshima, Koki Ishikawa, Yuki Naitou, Tatsushi Yokoyama, Masayuki Sakamoto, , Takeshi Imai

This paper develops a minimally invasive optical clearing medium for live mammalian tissue imaging, enabling structural and functional imaging with minimal impact on cellular properties.

Nature Methods · Mar 12, 2026Peer-reviewedNeuroscience

Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance

Peng Zhou, Rinshi S. Kasai, Wakako Fujita, Taka A. Tsunoyama, Hiroyuki Neyama, Hiroshi Ueda, Tatsushi Yokoyama, Masayuki Sakamoto, Simone Pigolotti A, Takahiro K. Fujiwara, Akihiro Kusumi

The paper uses single-molecule imaging to study opioid receptor heterodimerization and shows that blocking MOR-DOR heterodimers reduces morphine tolerance in mice.

Nature Communications · Nov 7, 2025Peer-reviewedBiophysics

Single-molecule detection of transient dimerization of opioid receptors 1: Homodimers' effect on signaling and internalization

Peng Zhou, Taka Aki Tsunoyama, Rinshi S. Kasai, Koichiro M. Hirosawa, Ziya Kalay, Amine Aladağ, Takahiro K Fujiwara, Tatsushi Yokoyama, Masayuki Sakamoto, Ryoji Kise, Masataka Yanagawa, Asuka Inoue, Simone Pigolotti A, Akihiro Kusumi

This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.

Nature Communications · Nov 7, 2025Peer-reviewedBiophysics

A multicolor suite for deciphering population coding in calcium and cAMP in vivo

Tatsushi Yokoyama, Satoshi Manita, Hiroyuki Uwamori, Mio Tajiri, Itaru Imayoshi, Sho Yagishita, Masanori Murayama, Kazuo Kitamura, Masayuki Sakamoto

The paper develops ultrasensitive cAMP and Ca2+ indicators to measure their dynamics in neurons and identifies their roles in signaling and behavior.

Nature Methods · Mar 21, 2024Peer-reviewedNeuroscience