Haruo Kasai

The paper develops uniSynK, a single-vector chemogenetic tool that optimizes the expression ratio of two components to robustly induce dendritic spine enlargement with fewer off-target effects.

This study shows that rapid associative spine enlargement is necessary for maintaining cognitive function and stable wakefulness in mice.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

The paper identifies a 1-second time window for reward conditioning in the nucleus accumbens of mice, dependent on dopamine D1 receptor and CaMKII signaling.

The paper reviews computational models showing that intrinsic synaptic dynamics can support stable network performance and may enhance information processing.

This paper introduces a reinforcement learning model inspired by the striatal dopamine system, showing it enables fast generalization and safe exploration but can also lead to maladaptive behaviors.

This study shows that structural plasticity in adult mouse neocortex in vivo occurs similarly to hippocampus in vitro but is more restricted in scope.

The paper shows that intrinsic spine dynamics stabilize cell assemblies and affect learning performance, particularly in autism spectrum disorder models.