Sho Yagishita

This study shows that rapid associative spine enlargement is necessary for maintaining cognitive function and stable wakefulness in mice.

This study shows microglia regulate the shift from Hebbian to three-factor plasticity rules in the medial prefrontal cortex during development, affecting social learning and pain sensitivity.

The paper shows that different antidepressants induce similar structural and molecular changes in the pallidum of mice, suggesting a common mechanism in their antidepressant effects.

The paper develops ultrasensitive cAMP and Ca2+ indicators to measure their dynamics in neurons and identifies their roles in signaling and behavior.

The paper develops a reinforcement learning model to capture choice behavior during progressive ratio tasks, finding that the Perseverance model with choice traces best explains behavioral responses to drug effects.

This paper identifies shared GABA transmission pathology in L-DOPA-induced and tardive dyskinesia models through structural and functional analysis of striatal neurons.

The paper shows that larger reward expectations in mice are associated with slower dopamine rise and larger dopamine dip in the ventral striatum during task performance.

The paper identifies a 1-second time window for reward conditioning in the nucleus accumbens of mice, dependent on dopamine D1 receptor and CaMKII signaling.

This paper introduces a reinforcement learning model inspired by the striatal dopamine system, showing it enables fast generalization and safe exploration but can also lead to maladaptive behaviors.

This study shows that structural plasticity in adult mouse neocortex in vivo occurs similarly to hippocampus in vitro but is more restricted in scope.