The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy
Meghan J. O’Melia, Kailan Sierra-Davidson, Miranda A. Robert, Lutz Menzel, Lingshan Liu, Pin‐Ji Lei, Lance L. Munn, Timothy P. Padera, Sonia Cohen
This study shows oncolytic virus therapy primarily elicits anti-virus T cell responses rather than anti-cancer responses, explaining limited clinical efficacy in metastatic disease.
bioRxiv · Sep 22, 2025 · PreprintImmunology