Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma
Elena Adán-Villaescusa, Borja Castelló-Uribe, Iker Uriarte, Eva Santamaría, Roberto Barbero, Miriam Belzunce, Amaya López-Pascual, Maria Ujue Latasa, Jasmin Elurbide, Emiliana Valbuena-Goiricelaya, Agavni Mesropian, Guillem Cano-Segarra, Ana Hernández de Sande, Lorenzo Nevi, Simone Carotti, , Maite G Fernandez-Barrena
This study shows that inhibiting G9a enhances the effectiveness of immune checkpoint inhibitors in hepatocellular carcinoma by improving tumor immunogenicity and T cell infiltration.
Cell Reports Medicine · Mar 31, 2026Peer-reviewedPharmacology & Toxicology