Iker Uriarte

Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma

This study identifies altered epigenetic regulators and metabolic genes in cholangiocarcinoma, linking them to poor prognosis and metabolic-epigenetic crosstalk.

Protein arginine-methyltransferase 1 (PRMT1): a new pharmacological target in cholangiocarcinoma

This study identifies PRMT1 as a critical driver of cholangiocarcinoma growth and immune evasion, showing its inhibition enhances antitumor immunity and synergizes with immunotherapy.

Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma

This study shows that inhibiting G9a enhances the effectiveness of immune checkpoint inhibitors in hepatocellular carcinoma by improving tumor immunogenicity and T cell infiltration.

Demonstration of SLU7 as a new pan-cancer target

This paper identifies SLU7 as a pan-cancer target, showing its knockdown induces genomic instability and enhances immunogenicity, with effective tumor suppression in murine models.