Antonio Pineda‐Lucena

Rational engineering of sdAb-based CAR T cells targeting BCMA enhances antitumor efficacy and persistence in Multiple Myeloma

This study engineers sdAb-based CAR T cells targeting BCMA, showing improved antitumor efficacy and persistence in multiple myeloma compared to existing therapies.

Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma

This study shows that inhibiting G9a enhances the effectiveness of immune checkpoint inhibitors in hepatocellular carcinoma by improving tumor immunogenicity and T cell infiltration.

GeNNius: An ultrafast drug-target interaction inference method based on graph neural networks

GeNNius uses a graph neural network to predict drug-target interactions more efficiently and accurately than existing methods across multiple datasets.

gMCStool: automated network-based tool to search for metabolic vulnerabilities in cancer

gMCStool identifies metabolic vulnerabilities in cancer by predicting synthetic lethal interactions using genome-scale metabolic networks and RNA-seq data.

Metabolic alterations in a Drosophila model of Parkinson's disease based on DJ-1 deficiency

This study investigates metabolic changes in a Drosophila Parkinson's disease model with DJ-1 deficiency, identifying altered pathways and potential therapeutic targets.