Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewing intestinal inflammation
Yusuke Yamashita, Hideki Kosako, Takashi Kato, Izumi Sasaki, Sadahiro Iwabuchi, Tadashi Okamura, Misato Tane, Shotaro Tabata, Kazutaka Nakashima, Ken‐ichiro Tanaka, Kazunori Shiraishi, Yuki Uchihara, Daisuke Okuzaki, Atsushi Shibata, Tsunehiro Mizushima, , Tsuneyasu Kaisho
This study shows that hypomorphic Lig4 mutation in mice causes Th1-skewed intestinal inflammation under adaptive immunodeficiency.
bioRxiv · May 14, 2025 · PreprintImmunology