Rashmi Kanagal‐Shamanna

This study uses spatial proteomics to reveal that TP53 mutant AML residual disease forms immunosuppressive niches in the bone marrow, segregated from T-cells, suggesting niche-level immune evasion.

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

This study evaluates Optical Genome Mapping (OGM) for detecting structural variants in myeloid neoplasms, showing high concordance and identifying additional clinically relevant variants compared to standard of care methods.

The paper describes the evolution of the CIViC knowledgebase to meet the needs of the cancer variant interpretation community by expanding its functionality and data types.

This study evaluates optical genome mapping's ability to detect chromosomal variants in MDS patients, showing high concordance with standard methods and identifying additional clinically relevant aberrations.

This study evaluates optical genome mapping (OGM) for detecting genomic aberrations in AML, finding it identifies all clinically relevant SVs and CNVs and detects additional variants missed by standard methods.