Koji Sasaki

Niche-level immune evasion in TP53 mutant AML residual disease revealed by spatial proteomics

This study uses spatial proteomics to reveal that TP53 mutant AML residual disease forms immunosuppressive niches in the bone marrow, segregated from T-cells, suggesting niche-level immune evasion.

Dual MYC and GSPT1 Protein Degrader for MYC-Driven Cancers

This paper identifies a novel MYC-GSPT1 feedback loop and reports a dual degrader, GT19630, that effectively targets MYC-driven cancers with anti-proliferative and apoptotic effects.

Evolutionary Action Score of TP53 Mutations: Integrated Clinico-pathologic And Protein Structural Analysis in Myelodysplastic Syndromes

The paper quantifies the impact of TP53 mutations in myelodysplastic syndromes using an evolutionary action score and correlates it with clinical and genomic features, finding that low-EAp53 mutations are associated with better survival.