Transcriptional profiling of the cortico-accumbal pathway reveals sex-specific alterations underlying stress susceptibility
André Moreira Pessoni, Laila Blanc Arabe, Luca Pancotti, Samaneh Mansouri, Marco D’Angelo, Karine Huot, Arturo Marroquín-Rivera, Modesto R. Peralta, Chenqi Zhao, Quentin Leboulleux, Martin Lévesque, Christophe D. Proulx, Benoît Labonté
This study identifies sex-specific transcriptional changes in mPFC-NAc pathway neurons under chronic stress, revealing Xlr4b as a stress susceptibility driver in males.
Biological Psychiatry · Oct 9, 2025Peer-reviewedNeuroscience