Author

Marina Lorente Picón

Biomedical Research Networking Center on Neurodegenerative DiseasesORCID 0000-0002-3629-9804Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 4

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Organism:human· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Alba NicolauiD· 3 shared Annabelle ParentiD· 3 shared Ariadna LagunaiD· 3 shared Marta González-SepúlvedaiD· 3 shared Miquel VilaiD· 3 shared Núria PeñuelasiD· 3 shared Camille Guillard-SirieixiD· 2 shared Helena XicoyiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Alba NicolauORCID

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4 papers

Recent·Most cited

Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

Núria Peñuelas, Helena Xicoy, Marina Lorente Picón, Alba Nicolau, Annabelle Parent, Marta González-Sepúlveda, Ariadna Laguna, Miquel Vila

This study identifies age-dependent neuroinflammatory changes in NM-containing neurons linked to neurodegeneration, with GPNMB as a conserved protective factor in Parkinson's disease.

bioRxiv · Aug 7, 2026 · PreprintNeuroscience

Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction

Cyril Bolduc, Maria Paulina Castelo Rueda, Marina Lorente Picón, Giovanna Gentile, Sreehari Kalvakuri, Victoria Soto Linan, Alessandra Zanon, Sofien Laouafa, Martin Lang, Alexandros Α. Lavdas, Valentina Gilmozzi, Greta Bernardo, Vincent Coulombe, Charles Gora, Modesto R. Peralta, , Martin Lévesque

This study shows that increasing SLP-2 levels reduces alpha-synuclein-induced mitochondrial damage and neurodegeneration in Parkinson's disease models.

bioRxiv · Jun 13, 2025 · PreprintNeuroscience

Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits

Ariadna Laguna, Núria Peñuelas, Marta González-Sepúlveda, Alba Nicolau, Sébastien Arthaud, Camille Guillard-Sirieix, Marina Lorente Picón, Joan Compte, Lluís Miquel-Rio, Helena Xicoy, Jiong Liu, Annabelle Parent, Thais Cuadros, Jordi Romero‐Giménez, Gemma Pujol, , Miquel Vila

This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.

Nature Communications · Oct 11, 2024Peer-reviewedNeuroscience

In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease

Marta González-Sepúlveda, Joan Compte, Thaïs Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Núria Peñuelas, Marina Lorente Picón, Annabelle Parent, Jordi Romero‐Giménez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila

This study reduces age-related neuromelanin accumulation in a humanized rodent model, mitigating Parkinson's disease features by preserving dopamine homeostasis and neuronal integrity.

Brain · Nov 23, 2022Peer-reviewedNeuroscience