Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction
Cyril Bolduc, Maria Paulina Castelo Rueda, Marina Lorente Picón, Giovanna Gentile, Sreehari Kalvakuri, Victoria Soto Linan, Alessandra Zanon, Sofien Laouafa, Martin Lang, Alexandros Α. Lavdas, Valentina Gilmozzi, Greta Bernardo, Vincent Coulombe, Charles Gora, Modesto R. Peralta, , Martin Lévesque
This study shows that increasing SLP-2 levels reduces alpha-synuclein-induced mitochondrial damage and neurodegeneration in Parkinson's disease models.
bioRxiv · Jun 13, 2025 · PreprintNeuroscience