Mediator complex subunit Med19 binds directly GATA DNA-binding zinc finger and functions with Med1 in GATA-driven gene regulation in vivo
Clément Immarigeon, Sandra Bernat-Fabre, Emmanuelle Guillou, Alexis Verger, Elodie Prince, Mohamed A. Benmedjahed, Adeline Payet, Marie Couralet, Didier Monté, Vincent Villeret, Henri-Marc G. Bourbon, Muriel Boube
The paper shows Med19 interacts with GATA TFs' zinc fingers and is critical for GATA-dependent gene regulation, distinct from Med1's role.
Journal of Biological Chemistry · Jul 31, 2020Peer-reviewedDevelopmental Biology