Sandra Bernat-Fabre

This study identifies a mechano-adaptive response in the colonic epithelium to mechanical stress, showing that myosin II and calcium influx coordinate junctional reinforcement to preserve barrier integrity.

This study shows that goblet cells create tight junction fractures between enterocytes, increasing gut permeability under homeostatic conditions and during hypertrophy.

This paper shows that increasing Med19 in Drosophila extends lifespan by 90%, delays frailty onset, and improves stress resistance, while reducing Med19 shortens lifespan and increases vulnerability to stress.

This study uses inducible degradation of Med19 in Drosophila to show it specifically regulates developmental genes but not constitutively expressed genes.

The paper investigates how enhancers regulate duplicated genes in Drosophila, showing differential activity and evolutionary conservation between tissue-specific and pleiotropic enhancers.

The paper shows Med19 interacts with GATA TFs' zinc fingers and is critical for GATA-dependent gene regulation, distinct from Med1's role.