Adeline Payet

The Mediator complex subunit Med19 extends healthy lifespan in Drosophila by preventing cellular and organismal frailty

This paper shows that increasing Med19 in Drosophila extends lifespan by 90%, delays frailty onset, and improves stress resistance, while reducing Med19 shortens lifespan and increases vulnerability to stress.

Inducible degradation of the Drosophila Mediator subunit Med19 reveals its role in regulating developmental but not constitutively-expressed genes

This study uses inducible degradation of Med19 in Drosophila to show it specifically regulates developmental genes but not constitutively expressed genes.

Mediator complex subunit Med19 binds directly GATA DNA-binding zinc finger and functions with Med1 in GATA-driven gene regulation in vivo

The paper shows Med19 interacts with GATA TFs' zinc fingers and is critical for GATA-dependent gene regulation, distinct from Med1's role.